Forti P, Maioli F, Zagni E, et al.

J Nutr Health Aging 2014;18:912-8

Publication date: December 1, 2014


The objective of this study was to determine the usefulness of physical phenotype of frailty, cognitive impairment and serum albumin for risk stratification of elderly medical inpatients.

Frailty was defined using the Study of Osteoporotic Fractures Index, a parsimonious version of the physical phenotype (two of the following markers: weight loss, inability to rise five times from a chair, and exhaustion). Two frailty markers from non-physical dimensions were also evaluated: cognitive impairment (Mini-Cog score < 3) and low serum albumin on ward admission (< 3.5 g/dL). Logistic regression adjusted for preadmission and admission-related confounders was used to investigate whether the physical phenotype of frailty and the two non-physical markers were associated with ward length of stay and unfavorable discharge (death plus any other ward discharge disposition different from direct return home).

The physical phenotype of frailty was associated with both study outcomes (P < 0.010) but the association was mainly mediated by chair standing ability. Non-physical markers were associated only with unfavorable discharge (P < 0.001). All of these predictors, either alone or in combination, had poor discriminatory ability (AUCs < 0.70) and poor clinical usefulness (+LRs near 1) for the study outcomes.

The physical phenotype of frailty appears of limited clinical use for risk stratification of older medical inpatients. Combination with markers from non-physical dimensions does not improve its prognostic abilities.


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